Early host cell-Molluscum contagiosum virus interactions.

Basal and suprabasal layers of human epidermis infected with the poxvirus Molluscum contagiosum have been examined with the technique of serial sectioning. Phagocytic vacuoles, formerly not observed in human epidermis, were found exclusively in the basal region. They did not fuse with other virus-containing vacuoles or with lysosomes to form digestive vacuoles. Various stages of uncoating, preceding ejection of the virus core into the cytoplasm, were observed in the virus-containing vacuole. Clusters of cores were commonly found close to or even associated with centriolar structures. Their possible interference with mitosis is discussed in relation to alterations observed in the plasma membrane. It is assumed that excision of gap junction elements precedes the induction of mitosis.