Finn J T, Grunwald M E, Yau K W
Thomas C. Jenkins Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Annu Rev Physiol. 1996;58:395-426. doi: 10.1146/annurev.ph.58.030196.002143.
An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.
大约十年前首次发现了一种直接由环鸟苷酸激活的离子通道。从那时起，已经报道了许多具有相同特性的离子通道（环核苷酸激活通道），它们参与多种细胞功能。此外，还发现了其他一些通道，它们并非主要受环核苷酸控制，但会受到其调节（环核苷酸调节通道）。这些通道同样具有多样的功能和组织分布。本文对这两类通道进行综述。内容包括这些通道上的环核苷酸结合位点、离子通透、药理学阻滞剂、通道门控与调节以及通道的生理功能。
