Biel M, Sautter A, Ludwig A, Hofmann F, Zong X
Institut für Pharmakologie und Toxikologie der Technischen Universität München, Munich, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):140-4. doi: 10.1007/pl00005235.
Cyclic nucleotide-gated (CNG) channels represent one of the three known cellular receptor classes for cGMP. Activation of CNG channels by binding of cyclic nucleotides to a site in the C-terminus results in opening of the channel pore, entry of Ca2+ into the cell and subsequent induction of Ca2+-dependent processes. In this review we will summarize new data on the complex molecular structure and the activation mechanism of CNG channels. In addition, we will discuss the role of CNG channels as mediators of NO:cGMP-dependent cellular processes.
环核苷酸门控（CNG）通道是已知的三种cGMP细胞受体类型之一。环核苷酸与C末端的一个位点结合，激活CNG通道，导致通道孔开放，Ca2+进入细胞，并随后诱导Ca2+依赖性过程。在本综述中，我们将总结关于CNG通道复杂分子结构和激活机制的新数据。此外，我们还将讨论CNG通道作为NO:cGMP依赖性细胞过程介质的作用。
