Importance of "first-pass elimination" for interindividual differences in steady-state concentrations of the adrenergic beta-receptor antagonist alprenolol.

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作者信息

Alván G, Lind M, Mellström B, von Bahr C

出版信息

J Pharmacokinet Biopharm. 1977 Jun;5(3):193-205. doi: 10.1007/BF01065395.

DOI:10.1007/BF01065395

PMID:881641

Abstract

摘要

相似文献

Importance of "first-pass elimination" for interindividual differences in steady-state concentrations of the adrenergic beta-receptor antagonist alprenolol.

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本文引用的文献

Gas chromatographic determination of the secondary amine alprenolol, as its trifluoroacetyl derivative, at nanogram levels in biological fluids.气相色谱法测定生物流体中纳克级的仲胺阿普洛尔（以其三氟乙酰衍生物形式）。

Acta Pharm Suec. 1969 Jun;6(3):393-400.

Influence of the route of administration on the area under the plasma concentration-time curve.给药途径对血浆浓度-时间曲线下面积的影响。

J Pharm Sci. 1969 Jan;58(1):71-5. doi: 10.1002/jps.2600580114.

Influence of first-pass effect on availability of drugs on oral administration.首过效应对口服给药时药物可利用度的影响。

J Pharm Sci. 1971 Sep;60(9):1338-40. doi: 10.1002/jps.2600600909.

Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果

Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.

The disposition of propranolol. I. Elimination during oral absorption in man.普萘洛尔的处置。I. 人体口服吸收过程中的消除

Pharmacology. 1972;7(3):159-68. doi: 10.1159/000136285.

Influence of route of administration on drug availability.给药途径对药物可利用性的影响。

J Pharm Sci. 1972 Jan;61(1):70-4. doi: 10.1002/jps.2600610111.

Relationship between dose and plateau levels of drugs eliminated by parallel first-order and capacity-limited kinetics.通过平行一级动力学和容量限制动力学消除的药物，其剂量与平台水平之间的关系。

J Pharm Sci. 1972 Apr;61(4):541-4. doi: 10.1002/jps.2600610409.

Combined pharmacokinetic and pharmacodynamic studies on alprenolol and 4-hydroxy-alprenolol in man.阿普洛尔和4-羟基阿普洛尔在人体中的药代动力学与药效学联合研究。

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Effect of route of administration on drug disposition.给药途径对药物处置的影响。

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Clearance concepts in pharmacokinetics.药代动力学中的清除概念。

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