细胞色素P - 450在β受体阻断药肝脏“首过消除”中的可能作用。 - Suppr

Suppr

超能文献

The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.

作者信息

Grundin R, Moldéus P, Orrenius S, Borg K O, Skånberg I, von Bahr C

出版信息

Acta Pharmacol Toxicol (Copenh). 1974 Sep;35(3):242-60. doi: 10.1111/j.1600-0773.1974.tb00744.x.

DOI:10.1111/j.1600-0773.1974.tb00744.x

PMID:4479306

Abstract

摘要

相似文献

The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.细胞色素P - 450在β受体阻断药肝脏“首过消除”中的可能作用。

Acta Pharmacol Toxicol (Copenh). 1974 Sep;35(3):242-60. doi: 10.1111/j.1600-0773.1974.tb00744.x.

Drug metabolism in isolated rat liver cells.大鼠离体肝细胞中的药物代谢

Adv Exp Med Biol. 1975;58(00):251-69.

Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.大鼠肝脏微粒体中细胞色素P - 450种类的表征，I. 苯巴比妥和3 - 甲基胆蒽预处理后7 - 乙氧基香豆素O - 脱烷基作用的差异

Hoppe Seylers Z Physiol Chem. 1973 May;354(5):514-20. doi: 10.1515/bchm2.1973.354.1.514.

A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.

Eur J Biochem. 1974 Jul 15;46(2):351-60. doi: 10.1111/j.1432-1033.1974.tb03627.x.

Proceedings: Isolated liver cells: a valuable tool for the study of drug metabolism.论文集：分离的肝细胞：药物代谢研究的宝贵工具。

Z Klin Chem Klin Biochem. 1975 Aug;13(8):375.

Metabolism of alprenolol in liver microsomes, perfused liver and conscious rat.

Acta Pharmacol Toxicol (Copenh). 1974 Sep;35(3):169-79. doi: 10.1111/j.1600-0773.1974.tb00735.x.

Microsomal drug oxidation. Function, induction, and inhibition of the cytochrome P450-system.微粒体药物氧化。细胞色素P450系统的功能、诱导及抑制作用。

Acta Vet Scand. 1973;14(1):11-21. doi: 10.1186/BF03547407.

Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.反式氧化茋、苯巴比妥和3-甲基胆蒽作为大鼠肝脏微粒体细胞色素P-450系统甾体代谢诱导剂的比较。

J Steroid Biochem. 1983 Apr;18(4):425-35. doi: 10.1016/0022-4731(83)90061-4.

Stoichiometric interaction of a beta-receptor blocking drug with fraction of liver cytochrome P-450 as a possible cause for its dose-dependent availability.一种β受体阻断药物与部分肝细胞色素P-450的化学计量相互作用可能是其剂量依赖性生物利用度的原因。

Acta Pharmacol Toxicol (Copenh). 1976 May;38(5):513-24. doi: 10.1111/j.1600-0773.1976.tb03147.x.

Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver.大鼠肠黏膜微粒体与肝脏药物代谢能力的比较。

Biochem Pharmacol. 1979 Sep 15;28(18):2835-9. doi: 10.1016/0006-2952(79)90569-0.

引用本文的文献

The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对脊髓麻醉大鼠肝脏中普萘洛尔首过消除的影响。

Br J Pharmacol. 1982 Dec;77(4):667-77. doi: 10.1111/j.1476-5381.1982.tb09345.x.

Pharmacokinetics and pharmacodynamics of propranolol stereoisomers in hyperthyroid patients.普萘洛尔立体异构体在甲状腺功能亢进患者中的药代动力学和药效学。

Eur J Clin Pharmacol. 1981 Feb;19(3):197-203. doi: 10.1007/BF00561949.

Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthine.美托洛尔在年轻人和老年人中的生物利用度，以及关于甲氧氯普胺和丙胺太林作用的补充研究。

Eur J Clin Pharmacol. 1983;25(3):353-6. doi: 10.1007/BF01037947.

Decreased plasma concentrations and clinical effects of alprenolol during combined treatment with pentobarbitone in hypertension.在高血压患者中，戊巴比妥与阿普洛尔联合治疗期间，阿普洛尔的血浆浓度降低及其临床效应。

Br J Clin Pharmacol. 1987 Mar;23(3):267-71. doi: 10.1111/j.1365-2125.1987.tb03044.x.

Importance of "first-pass elimination" for interindividual differences in steady-state concentrations of the adrenergic beta-receptor antagonist alprenolol.

J Pharmacokinet Biopharm. 1977 Jun;5(3):193-205. doi: 10.1007/BF01065395.

First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma.去甲替林的首过羟基化作用：血浆中母体药物及主要代谢物的浓度

Eur J Clin Pharmacol. 1977 Mar 11;11(3):219-24. doi: 10.1007/BF00606414.

Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat.

J Pharmacokinet Biopharm. 1978 Aug;6(4):327-37. doi: 10.1007/BF01060096.

Clinical pharmacokinetics of beta-adrenoreceptor blocking drugs.β-肾上腺素受体阻断药的临床药代动力学

Clin Pharmacokinet. 1976;1(4):233-63. doi: 10.2165/00003088-197601040-00001.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验