Franke-Ullmann G, Pförtner C, Walter P, Steinmüller C, Lohmann-Matthes M L, Kobzik L
Department of Immunology, Fraunhofer-Institute for Toxicology and Aerosol Research, Hannover, Germany.
J Immunol. 1996 Oct 1;157(7):3097-104.
The present study was performed to characterize the immunologic potential of interstitial macrophages (INT) in comparison with alveolar macrophages (AL). The data showed that AL, compared with INT, have a more efficient phagocytic potential. In addition, they have a strong microbicidal activity and secrete large amounts of reactive oxygen radicals, nitric oxides, TNF, and IFN on appropriate stimulation. They also exert strong tumoricidal and parasiticidal activities. In contrast, INT are more efficient in releasing immunoregulatory cytokines such as IL-1 and IL-6. As determined by Ab staining, INT express more MHC class II molecules and are more effective in functioning as accessory cells for mitogen-stimulated lymphocyte proliferation compared with AL. Thus, AL appear to be particularly effective as nonspecific first line defense cells against infectious agents, whereas INT are equipped to cooperate with interstitial lymphocytes in inducing a specific immune reaction.
本研究旨在比较间质巨噬细胞（INT）与肺泡巨噬细胞（AL）的免疫潜能。数据显示，与INT相比，AL具有更高效的吞噬潜能。此外，它们具有强大的杀菌活性，在适当刺激下可分泌大量活性氧自由基、一氧化氮、肿瘤坏死因子（TNF）和干扰素（IFN）。它们还具有强大的杀肿瘤和杀寄生虫活性。相比之下，INT在释放免疫调节细胞因子如白细胞介素-1（IL-1）和白细胞介素-6方面更有效。通过抗体染色测定，与AL相比，INT表达更多的MHC II类分子，并且在作为丝裂原刺激的淋巴细胞增殖的辅助细胞方面更有效。因此，AL似乎作为针对感染因子的非特异性一线防御细胞特别有效，而INT则准备好与间质淋巴细胞合作诱导特异性免疫反应。
