Fowler R E, Johnson M H, Walters D E, Eager D D
J Reprod Fertil. 1977 Jul;50(2):301-8. doi: 10.1530/jrf.0.0500301.
A detailed study has been made of the progesterone content of uterine flushings taken from rabbits of different endocrine states. A high content of progesterone was recovered from the uterine lumen of pregnant and pseudopregnant rabbits. The amount of progesterone recovered in the flushings was not simply dependent on the concentration in the plasma, because plasma progesterone concentrations rose before detection of progesterone in the flushings and remained high after uterine progesterone content had fallen. Progesterone did not appear in the uterine fluid unless uterine protein was present. This was particularly evident in rabbits treated with progesterone in which, despite abnormally high plasma concentrations, little progesterone was found in uterine fluid until the protein content increased. After treatment of rabbits with oestrogen at the time of ovulation, uterine progesterone was present in higher amounts concomitant with an elevation of protein content although the peak values of progesterone and protein were delayed by 2--3 days. Plasma progesterone concentrations of about 5 ng/ml were necessary before progesterone appeared in the uterine lumen.
对处于不同内分泌状态的家兔子宫冲洗液中的孕酮含量进行了详细研究。从怀孕和假孕家兔的子宫腔中回收了高含量的孕酮。冲洗液中回收的孕酮量并非简单地取决于血浆中的浓度，因为在冲洗液中检测到孕酮之前血浆孕酮浓度就已升高，并且在子宫孕酮含量下降后仍保持在高位。除非子宫中有蛋白质存在，否则孕酮不会出现在子宫液中。这在用孕酮处理的家兔中尤为明显，尽管血浆浓度异常高，但在蛋白质含量增加之前，子宫液中几乎检测不到孕酮。在排卵时用雌激素处理的家兔，随着蛋白质含量的升高，子宫孕酮含量也更高，尽管孕酮和蛋白质的峰值出现时间延迟了2 - 3天。在孕酮出现在子宫腔之前，血浆孕酮浓度约需达到5 ng/ml。
