嗅周海马通路中的长时程增强是NMDA受体依赖性的。
Long-term potentiation in the perirhinal-hippocampal pathway is NMDA dependent.
作者信息
Liu P, Bilkey D K
机构信息
Department of Psychology, University of Otago, Dunedin, New Zealand.
出版信息
Neuroreport. 1996 May 17;7(7):1241-4. doi: 10.1097/00001756-199605170-00003.
The putative memory mechanism known as long-term potentiation (LTP) has been described in both NMDA-dependent and non-NMDA-dependent forms. The aim of the present study was to determine which of these forms described the LTP generated between perirhinal cortex (PRC) and hippocampus, two structures which have previously been implicated in learning and memory processes. In urethane-anaesthetized rats, high-frequency stimulation of the PRC induced a significant potentiation of PRC-hippocampal field potentials which was blocked by the NMDA receptor antagonist, MK-801. These data demonstrate that perirhinal-hippocampal LTP is NMDA-dependent and, moreover, that hippocampal-dependent learning which occurs during blockade of the NMDA receptor cannot be attributed to LTP of this pathway.
被称为长时程增强（LTP）的假定记忆机制已被描述为依赖N-甲基-D-天冬氨酸（NMDA）和不依赖NMDA的两种形式。本研究的目的是确定这些形式中的哪一种描述了内嗅皮质（PRC）和海马体之间产生的LTP，这两个结构先前已被认为与学习和记忆过程有关。在经乌拉坦麻醉的大鼠中，对PRC进行高频刺激可诱导PRC-海马体场电位的显著增强，这被NMDA受体拮抗剂MK-801阻断。这些数据表明，内嗅-海马体LTP是依赖NMDA的，此外，在NMDA受体阻断期间发生的依赖海马体的学习不能归因于该通路的LTP。
Zotero 插件