Matthias F R, Krause W H, Ganssert S, Mueller K, Lasch H G
Klin Wochenschr. 1977 Jun 1;55(11):539-43. doi: 10.1007/BF01489349.
A new case of dysfibrinogenemia is reported which shows no signs of a haermorrhagic diathesis (dysfibrinogenemia Giessen III). The abnormal fibrinogen was detected by only slight but characteristic alterations of some parameter of the coagulation analysis (prolonged clotting times after addition of thrombin, Reptilase and thrombin coagulase; low fibrinogen concentration determined by methods based on clot formation in comparison to the immunological fibrinogen determination; delayed fibrin polymerization). In addition, clinical features and diagnosis of dysfibrinogenemia are described in general.
报道了一例新的异常纤维蛋白原血症病例,该病例无出血素质迹象(吉森III型异常纤维蛋白原血症)。通过凝血分析某些参数仅轻微但具有特征性的改变检测到异常纤维蛋白原(添加凝血酶、蛇毒凝血酶和凝血酶凝固酶后凝血时间延长;与免疫学法测定纤维蛋白原相比,基于凝块形成的方法测定的纤维蛋白原浓度低;纤维蛋白聚合延迟)。此外,还概述了异常纤维蛋白原血症的临床特征和诊断。