Simmons E D, Guntupalli M, Kowalski J M, Braun F, Seidel T
Department of Orthopaedic Surgery, Buffalo General Hospital, State University of New York at Buffalo, USA.
Spine (Phila Pa 1976). 1996 Jul 1;21(13):1527-9. doi: 10.1097/00007632-199607010-00007.
This case-control study was undertaken to determine if relatives of patients who had been admitted for surgery for degenerative disc disease-related problems were at increased risk for lower back pain or sciatica.
To determine if familial factors play a role in placing a person at risk for development of degenerative disc disease of the lumbar spine.
It is known that smoking and various occupational factors can place a person at risk for degenerative disc disease problems. It is not known if a familial predisposition may also exist.
The family members and relatives of 65 patients who had undergone surgery for lumbar degenerative disc disease were interviewed with a standardized questionnaire and compared with a control group of 67 patients who had been admitted to hospital for non-spine-related orthopedic procedures. The same interview and standardized questionnaire was used for both groups by a single observer.
In the study group of 65 patients who had undergone surgery for degenerative disc disease, 44.6% were noted to have a positive family history, whereas 25.4% of the patients in the control group had a positive family history. Eighteen and one-half percent of relatives in the study group had a history of having spinal surgery, compared with only 4.5% of the control group.
The results indicate that a familial predisposition to degenerative disc disease can exist along with other risk factors.
本病例对照研究旨在确定因退行性椎间盘疾病相关问题接受手术治疗的患者亲属患下背痛或坐骨神经痛的风险是否增加。
确定家族因素是否在使个体患腰椎退行性椎间盘疾病的风险中起作用。
已知吸烟和各种职业因素会使个体有患退行性椎间盘疾病问题的风险。尚不清楚是否也存在家族易感性。
对65例接受腰椎退行性椎间盘疾病手术的患者的家庭成员和亲属进行标准化问卷调查，并与67例因非脊柱相关骨科手术入院的对照组患者进行比较。两组均由一名观察者使用相同的访谈和标准化问卷。
在65例接受退行性椎间盘疾病手术的研究组患者中，44.6%有阳性家族史，而对照组患者中有25.4%有阳性家族史。研究组中18.5%的亲属有脊柱手术史，而对照组仅为4.5%。
结果表明，除其他风险因素外，退行性椎间盘疾病可能存在家族易感性。
