Varlotta G P, Brown M D, Kelsey J L, Golden A L
Department of Orthopaedics and Rehabilitation, University of Miami School of Medicine, Florida 33101.
J Bone Joint Surg Am. 1991 Jan;73(1):124-8.
The parents of sixty-three patients who were less than twenty-one years old and who had operatively confirmed herniation of a lumbar disc were interviewed regarding a history of sever back pain, sciatica, and herniated disc, to determine whether aggregation of herniation of a lumbar disc occurs in families of patients in this young age-group. The parents of sixty-three additional patients who had a non-spinal orthopaedic diagnosis (control group) were matched for age and sex with the study group and were given the same interview. Of the patients who had herniation of a lumbar disc and were less than twenty-one years old, 32 per cent had a positive family history for that lesion compared with 7 per cent of the control group. The relative risk of development of herniation of a lumbar disc before the age of twenty-one years is estimated to be approximately five times greater in patients who have a positive family history. The results indicate a familial basis for herniation of a lumbar disc in patients who are less than twenty-one years old.
我们访谈了63名年龄小于21岁且经手术确诊为腰椎间盘突出症患者的父母，询问他们孩子严重背痛、坐骨神经痛和椎间盘突出的病史，以确定在这个年轻年龄组患者的家庭中是否存在腰椎间盘突出症聚集现象。另外选取63名患有非脊柱骨科疾病诊断的患者（对照组）的父母，按照年龄和性别与研究组进行匹配，并给予相同的访谈。在年龄小于21岁的腰椎间盘突出症患者中，32%有该疾病的阳性家族史，而对照组这一比例为7%。据估计，有阳性家族史的患者在21岁之前发生腰椎间盘突出症的相对风险大约是其他患者的五倍。结果表明，年龄小于21岁的腰椎间盘突出症患者存在家族性发病基础。
