Choong P F, Mandahl N, Mertens F, Willén H, Alvegård T, Kreicbergs A, Mitelman F, Rydholm A
Department of Orthopedics, University Hospital, Lund, Sweden.
Genes Chromosomes Cancer. 1996 Jun;16(2):88-93. doi: 10.1002/(SICI)1098-2264(199606)16:2<88::AID-GCC2>3.0.CO;2-Z.
In this study, we examined the relationship of 19p13 aberrations, usually leading to addition of unknown material (19p+), and ring chromosomes to clinical outcome in patients with malignant fibrous histiocytoma (MFH). Analysis of 69 MFHs revealed 19 tumors with 19p+ and 24 tumors with ring chromosomes. After a median follow-up period of 36 months, 24 patients developed metastases, and 27 patients developed local recurrences. Ten patients had both local recurrences and metastases. Local recurrence was more common in association with 19p+ than without. Metastasis was more common with 19p+ tumors in high-risk patients (tumor size > 5 cm and grade III-IV; n = 48) than those without 19p+. There was a trend suggesting fewer relapses after tumors with ring chromosomes. 19p+ may be an independent marker of unfavorable outcome in MFH.
在本研究中，我们检测了19号染色体短臂1区3带（19p13）异常（通常导致未知物质附加，即19p+）以及环状染色体与恶性纤维组织细胞瘤（MFH）患者临床预后的关系。对69例MFH进行分析，发现19例存在19p+，24例存在环状染色体。中位随访期为36个月后，24例患者发生转移，27例患者出现局部复发。10例患者既有局部复发又有转移。19p+相关的局部复发比无19p+的情况更常见。在高危患者（肿瘤大小>5 cm且分级为III-IV级；n = 48）中，19p+肿瘤发生转移比无19p+肿瘤更常见。有一个趋势表明，环状染色体肿瘤后的复发较少。19p+可能是MFH不良预后的一个独立标志物。
