Planché C, Weiss M, Verriest C
J Thorac Cardiovasc Surg. 1977 Aug;74(2):238-43.
A study of two-stage pulmonary autotransplantation was performed on 29 dogs; 12 dogs died after the first stage, which was always a right lung reimplantation, and 17 dogs underwent the second stage after varying intervals of time. In the group of six dogs operated upon with very short intervals between stages (2 to 8 days) there were no survivors. There were seven long-term survivors in the subgroup with an interval longer than 4 weeks, and they constitute the largest published series obtained with this particular procedure. The interval between operative stages was the only significant controlled variable, as only minor technical or operative differences were allowed to occur. Ischemia times of the lungs were usually quite short. The surviving animals were utilized for studies of the regeneration of the afferent pulmonary nerves (Hering-Breure reflex and effects of capsaicin) as permitted by a long follow-up period of up to 3 years.
对29只犬进行了两阶段肺自体移植研究；12只犬在第一阶段（始终是右肺再植入）后死亡，17只犬在不同时间间隔后进行了第二阶段手术。在两阶段间隔时间非常短（2至8天）接受手术的6只犬组中无存活者。在间隔时间超过4周的亚组中有7只长期存活者，它们构成了用此特定手术获得的已发表的最大系列病例。手术阶段之间的间隔是唯一显著的可控变量，因为只允许出现微小的技术或手术差异。肺的缺血时间通常相当短。存活的动物用于研究传入肺神经的再生（黑林 - 布雷尔反射和辣椒素的作用），这得益于长达3年的长期随访期。
