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蛋白磷酸酶2C（PP2C）超家族：细菌同源物的检测

The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues.

作者信息

Bork P, Brown N P, Hegyi H, Schultz J

机构信息

European Molecular Biology Laboratory, Heidelberg, Germany.

出版信息

Protein Sci. 1996 Jul;5(7):1421-5. doi: 10.1002/pro.5560050720.

DOI:10.1002/pro.5560050720
PMID:8819174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2143460/
Abstract

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

摘要

对真核生物蛋白丝氨酸/苏氨酸磷酸酶2C（PP2C）家族的各个成员进行全面的序列分析，发现了11个基序的保守性。这些基序可以在许多其他序列中识别出来，包括预计含有功能活性PP2C结构域的真菌腺苷酸环化酶，以及包括SpoIIE在内的原核丝氨酸/苏氨酸磷酸酶家族。对所有蛋白质的系统发育分析表明，这是一个广泛存在的序列家族，可以推断出相当数量的同工酶。

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本文引用的文献

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Applying motif and profile searches.应用基序和轮廓搜索。
Methods Enzymol. 1996;266:162-84. doi: 10.1016/s0076-6879(96)66013-3.
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Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome.单细胞蓝藻聚球藻属6803菌株（Synechocystis sp. strain PCC6803）基因组的序列分析。I. 基因组图谱位置64%至92%的1兆碱基区域的序列特征。
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Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C.牛丙酮酸脱氢酶磷酸酶催化亚基的分子克隆与表达及其与蛋白磷酸酶2C的序列相似性
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Bacterial and bacteriophage protein phosphatases.细菌和噬菌体蛋白磷酸酶。
Mol Microbiol. 1993 May;8(4):785-6. doi: 10.1111/j.1365-2958.1993.tb01622.x.
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A protein phosphatase 2C involved in ABA signal transduction in Arabidopsis thaliana.一种参与拟南芥脱落酸信号转导的蛋白磷酸酶2C。
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TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation.酿酒酵母的TPD1编码一种与tRNA剪接和细胞分离有关的类蛋白磷酸酶2C活性。
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PHD--an automatic mail server for protein secondary structure prediction.PHD——一种用于蛋白质二级结构预测的自动邮件服务器。
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Hormonal induction of low affinity receptor guanylyl cyclase.低亲和力受体鸟苷酸环化酶的激素诱导
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Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.蛋白质中保守片段的检测：使用比对模块对序列数据库进行迭代扫描。
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12091-5. doi: 10.1073/pnas.91.25.12091.
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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.CLUSTAL W：通过序列加权、位置特异性空位罚分和权重矩阵选择提高渐进多序列比对的灵敏度。
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