Chopra R, Kumar S, Rana R, Zachariah A
Departments of Pathology and Medicine, Christian Medical College, Ludhiana.
Indian J Pathol Microbiol. 1995 Jul;38(3):267-71.
Bone marrow involvement was observed in 7 cases amongst a total of 75 cases of Hodgkin's disease encountered between January 1981 and June 1990; thus representing an incidence of 9.3 percent. Analysis of these 7 cases showed male preponderance. The age ranged from 26 to 74 years. All patients presented within seven months of onset of symptoms; and all had symptoms at presentation. Lymphadenopathy was found in all the cases, splenomegaly was present in six; and hepatomegaly in 4 cases. Mixed cellularity and lymphocytic depletion subtypes showed the highest frequency of marrow involvement (6 cases; 85.7 percent). Alkaline phosphatase was raised in 6 cases (85.7%). All cases received standard combination chemotherapy with or without local radiation therapy. Two years follow-up revealed an overall survival of 42.9%. Replace free survival at the end of two years was zero, as all the cases relapsed within seven months of initiation of treatment.
在1981年1月至1990年6月期间收治的75例霍奇金病患者中，有7例观察到骨髓受累，发病率为9.3%。对这7例患者的分析显示男性居多。年龄范围为26至74岁。所有患者在症状出现后7个月内就诊，且就诊时均有症状。所有病例均发现有淋巴结病，6例有脾肿大，4例有肝肿大。混合细胞型和淋巴细胞消减型骨髓受累频率最高（6例，85.7%）。6例（85.7%）碱性磷酸酶升高。所有病例均接受了标准联合化疗，部分接受或未接受局部放射治疗。两年随访显示总生存率为42.9%。两年末的无复发生存率为零，因为所有病例在开始治疗后7个月内均复发。
