Cosmi E V, Cantini L, Monici Preti P A, Di Renzo G C, Abate F, Balsotti G, Carlomagno G, Cirese E, Indraccolo R, La Sala G B, Mearini L, Minozzi M, Scarpello F
2nd Department of Gynaecology and Obstetrics, 'La Sapienza' University, Roma, Italy.
Eur J Obstet Gynecol Reprod Biol. 1996 Feb;64(2):207-11. doi: 10.1016/0301-2115(95)02292-9.
In an open study, 172 male and female adult patients with acute uncomplicated bacterial cystitis were randomly allocated to three treatment groups. Two groups received brodimoprim 200 mg tablets as follows: a single dose of two 200 mg tablets on day 1, followed by one tablet per day on days 2 and 3 (58 patients); or a single daily dose of two tablets, for 2 days (63 patients). The third group received a single dose of pefloxacin, as two 400 mg tablets, for 1 day (51 patients). Complete urinalysis, sediment and urine culture examinations were carried out before treatment and 10 days after the last dose. Evaluation also comprised, at the time of enrolment and 48 h after the last dose, measurement of corporal temperature and assessment of symptoms (dysuria, pollakiuria, strangury, suprapubic pain, burning sensation during urination and urgency) on a 4-point scale. The eradication rate for the pathogen concerned was 98.3% and 96.7% in the groups receiving brodimoprim for 3 and 2 days, respectively, and 92.8% in the pefloxacin group (between-group comparison n.s.). There was significant regression of symptoms (P < 0.001) in the three groups (between-groups comparison n.s.). Mainly gastrointestinal adverse events occurred in 3 patients receiving brodimoprim for 2 days and in 4 patients from each of the other two groups.
在一项开放性研究中，172例成年男女急性单纯性细菌性膀胱炎患者被随机分为三组。两组接受溴莫普明200毫克片剂，给药方式如下：第1天单次服用两片200毫克片剂，随后在第2天和第3天每天服用一片（58例患者）；或每天单次服用两片，共2天（63例患者）。第三组接受单剂量的培氟沙星，两片400毫克片剂，服用1天（51例患者）。在治疗前和最后一剂后10天进行了完整的尿液分析、沉渣和尿培养检查。评估还包括在入组时和最后一剂后48小时测量体温，并按4分制评估症状（排尿困难、尿频、尿急、耻骨上疼痛、排尿时烧灼感和紧迫性）。接受溴莫普明治疗3天和2天的组中，相关病原体的根除率分别为98.3%和96.7%，培氟沙星组为92.8%（组间比较无统计学意义）。三组症状均有显著缓解（P<0.001）（组间比较无统计学意义）。接受溴莫普明治疗2天的3例患者以及其他两组各4例患者主要出现胃肠道不良事件。
