Emel'ianov A V, Trofimov V I
Ter Arkh. 1995;67(12):31-3.
Nuclear-absorption spectrophotometry (AAC-508, Hitachi, Japan) and selective ionometry (microlyte, Kone, Finland) were employed to measure magnesium and calcium concentrations in the serum, red cells, lymphocytes, 24-h urine and exhaled air moisture in 40 patients with hormone-dependent asthma (BA) and 15 BA patients given beclomet, becotid in inhalations and injections of hydrocortisone, prednisolone and dexason. Intravenous infusions and steroid inhalations in moderate doses for 10-14 days induce only insignificant changes in bivalent cation homeostasis. Complications associated with deranged mineral metabolism occurred more frequently in BA patients on long-term (at least 4 years) courses of oral glucocorticoids. Increased renal and bronchial excretion of magnesium and calcium in patients with hormone-dependent BA with complications of glucocorticoid therapy shows its significant contribution to development of steroid osteopathy and myopathy.
采用核吸收分光光度法（日本日立公司的AAC - 508）和选择性离子分析法（芬兰科恩公司的微量电解质分析仪），对40例激素依赖性哮喘（BA）患者以及15例接受倍氯米松、丙酸倍氯米松吸入治疗和氢化可的松、泼尼松龙及地塞米松注射治疗的BA患者的血清、红细胞、淋巴细胞、24小时尿液和呼出气体中的水分进行镁和钙浓度测定。以中等剂量进行10 - 14天的静脉输注和类固醇吸入，只会引起二价阳离子稳态的微小变化。在长期（至少4年）口服糖皮质激素治疗的BA患者中，与矿物质代谢紊乱相关的并发症更为常见。激素依赖性BA患者伴有糖皮质激素治疗并发症时，镁和钙的肾脏及支气管排泄增加，这表明其对类固醇性骨病和肌病的发生有显著影响。
