Emel'ianov A V, Trofimov V I
Klin Med (Mosk). 1995;73(2):23-5.
Magnesium and calcium levels in the serum, red cells, lymphocytes, circadian urine and exhaled air condensate were measured in 40 patients with hormone-dependent bronchial asthma (BA) and 15 BA patients receiving glucocorticoids in inhalations (beclamete, becotide) and injections (hydrocortisone, prednisolone, dexasone). Nuclear absorption spectrophotometry (AAC-508, Hitachi, Japan) and selective ionometry (Mycrolyte, Kone, Finland) were employed. Short-term (10-14 days) intravenous infusions and inhalations of steroids in medium therapeutic doses do not change much homeostasis of two-valent cations. Complications resultant from disturbance of mineral metabolism developed more frequently in BA patients on long-term (4 years more longer) oral glucocorticoids. Increased renal and bronchial excretion of magnesium and calcium in patients with hormone-dependent BA having complications of glucocorticoid therapy suggests that derangement of mineral metabolism is involved in the onset of steroid osteopathy and myopathy.
对40例激素依赖性支气管哮喘（BA）患者以及15例接受吸入（倍氯米松、必可酮）和注射（氢化可的松、泼尼松龙、地塞米松）糖皮质激素治疗的BA患者，测定了其血清、红细胞、淋巴细胞、24小时尿及呼出气冷凝液中的镁和钙水平。采用了核吸收分光光度法（日本日立公司的AAC - 508）和选择性离子测定法（芬兰康泰公司的Mycrolyte）。短期（10 - 14天）静脉输注和吸入中等治疗剂量的类固醇，对二价阳离子的体内平衡改变不大。长期（4年及以上）口服糖皮质激素的BA患者，更常出现因矿物质代谢紊乱导致的并发症。患有激素依赖性BA且有糖皮质激素治疗并发症的患者，其肾脏和支气管对镁和钙的排泄增加，这表明矿物质代谢紊乱与类固醇性骨病和肌病的发病有关。
