患有智力缺陷的攻击性个体的血小板异常。
Platelet abnormalities in aggressive subjects with mental deficiency.
作者信息
Marazziti D, Palego L, Silvestri S, Presta S, Balestri C, Batistini A, Conti L
机构信息
Institute of Psychiatry, University of Pisa, Italy.
出版信息
J Psychiatry Neurosci. 1996 Mar;21(2):109-13.
Platelet 3H-imipramine (3H-IMI) binding and platelet sulfotransferase (ST) activity, taken as markers of the serotonin (5-HT) and sulfated neurotransmitters (tyramine, dopamine, serotonin, noradrenaline), respectively, were evaluated in 14 severely aggressive subjects institutionalized since childhood for mental retardation and in an equal number of healthy controls. The results showed the presence of a lower number of 3H-IMI binding sites and a higher ST activity in the patients as compared with controls. These data provide supporting evidence for the hypothesis of an abnormality of the 5-HT system and suggest possible dysfunctions of dopamine and sulfated amines in aggressive behavior, at least as reflected by platelet markers.
以血小板3H-丙咪嗪（3H-IMI）结合和血小板磺基转移酶（ST）活性分别作为血清素（5-HT）和硫酸化神经递质（酪胺、多巴胺、血清素、去甲肾上腺素）的标志物，对14名自童年起就因智力迟钝而被收容的严重攻击性受试者以及同等数量的健康对照者进行了评估。结果显示，与对照组相比，患者体内3H-IMI结合位点数量较少，ST活性较高。这些数据为5-HT系统异常的假说提供了支持证据，并表明多巴胺和硫酸化胺在攻击行为中可能存在功能障碍，至少从血小板标志物反映出来是这样。
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