Marazziti D, Hollander E, Lensi P, Ravagli S, Cassano G B
2nd Chair of Psychiatric Clinic, Medical School, University of Pisa, Italy.
Psychiatry Res. 1992 Apr;42(1):41-51. doi: 10.1016/0165-1781(92)90037-4.
In an attempt to clarify the possible role of a serotonergic and dopaminergic dysfunction in obsessive-compulsive disorder (OCD), we measured platelet 3H-imipramine (3H-IMI) binding, serotonin uptake, and platelet sulfotransferase activity in 17 drug-free OCD patients and an equal number of healthy controls. Serotonin uptake and 3H-IMI binding sites in platelets have been shown to constitute peripheral markers of those present in presynaptic serotonergic neurons. Sulfotransferase, an enzyme involved in the catabolism of phenolic compounds and of cathecholamines such as dopamine, has similar kinetic characteristics in brain and platelets. Our results showed a lower number of 3H-IMI binding sites and a higher level of sulfotransferase activity in OCD patients compared with those in controls. These preliminary results suggest involvement of both the serotonin and dopamine systems in OCD.
为了阐明血清素能和多巴胺能功能障碍在强迫症（OCD）中可能发挥的作用，我们检测了17名未服用药物的强迫症患者及数量相同的健康对照者的血小板3H-丙咪嗪（3H-IMI）结合力、血清素摄取及血小板磺基转移酶活性。血小板中的血清素摄取及3H-IMI结合位点已被证明是突触前血清素能神经元中相应位点的外周标志物。磺基转移酶是一种参与酚类化合物和多巴胺等儿茶酚胺分解代谢的酶，在大脑和血小板中具有相似的动力学特征。我们的结果显示，与对照组相比，强迫症患者的3H-IMI结合位点数较少，磺基转移酶活性较高。这些初步结果表明血清素和多巴胺系统均与强迫症有关。
