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长期接触铅和硫化合物可能会引发帕金森病。

Chronic intoxication with lead- and sulfur compounds may produce Parkinson's disease.

作者信息

Winkel R, Kuhn W, Przuntek H

机构信息

Department of Neurology, Ruhr-University Bochum, Federal Republic of Germany.

出版信息

J Neural Transm Suppl. 1995;46:183-7.

PMID:8821054
Abstract

Parkinson's disease was found in three post office workers who were in close contact with lead-sulfate batteries over a period between 1947 and 1983. The workers had been working in a charging station for lead storage batteries used for the battery-traction of post wagons. Parkinson's disease was diagnosed by the characteristic features of rigidity, tremor and elements of hypo-, brady- and akinesia. Additional symptoms were: bradyphrenia (n = 3), memory deficits (n = 3), depressive symptoms (n = 2) and peripheral neuropathy (n = 2). We hypothesize that the parkinsonian symptoms of these post office workers are primarily caused by lead or lead compounds. However a possible toxicity of sulfur containing compounds cannot be ruled out.

摘要

在1947年至1983年期间,三名与硫酸铅电池密切接触的邮局工作人员被发现患有帕金森病。这些工作人员一直在一个用于邮政马车电池牵引的铅蓄电池充电站工作。帕金森病是根据僵硬、震颤以及运动减退、运动徐缓和运动不能等特征来诊断的。其他症状包括:智力迟钝(3例)、记忆缺陷(3例)、抑郁症状(2例)和周围神经病变(2例)。我们推测这些邮局工作人员的帕金森症状主要是由铅或铅化合物引起的。然而,含硫化合物的潜在毒性也不能排除。

相似文献

1
Chronic intoxication with lead- and sulfur compounds may produce Parkinson's disease.长期接触铅和硫化合物可能会引发帕金森病。
J Neural Transm Suppl. 1995;46:183-7.
2
[The clinical picture and diagnosis of manganese-induced parkinsonism].[锰中毒所致帕金森综合征的临床表现与诊断]
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[State of the cardiovascular system in workers exposed to lead].[铅暴露工人的心血管系统状况]
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Occupational and environmental causes of parkinsonism.帕金森症的职业与环境成因。
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Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users.一组持牌农药使用者中帕金森病风险的评估。
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[Parkinson's disease and rural environment].[帕金森病与农村环境]
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[Neuronal activities in the ventrolateral thalamus and basal ganglia in relation to Parkinson's disease].[与帕金森病相关的丘脑腹外侧核和基底神经节的神经元活动]
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[Contact sensitivity to lead].[对铅的接触性敏感]
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Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity.三氯乙烯:帕金森综合征与线粒体复合体I神经毒性
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Radial neuropathy due to occupational lead exposure: Phenotypic and electrophysiological characteristics of five patients.职业性铅暴露所致桡神经病变:5例患者的表型和电生理特征
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Conjugal Parkinsonism and Parkinson disease: a case series with environmental risk factor analysis.配偶型帕金森病与帕金森病:伴有环境风险因素分析的病例系列。
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Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster.数量性状基因座(QTL)的变异会影响暴露于铅的黑腹果蝇行为的发育。
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