Grégoire M, Lieubeau B
Institut de Biologie, INSERM U419, Nantes, France.
Cancer Metastasis Rev. 1995 Dec;14(4):339-50. doi: 10.1007/BF00690602.
The prominent desmoplastic or stromal reaction seen in many invasive carcinomas suggests that stromal cells play a role in cancer pathogenesis. Investigations based on cell typing, using antibodies to cytoskeletal constituents, have revealed that most tumors contain various types of fibroblasts. Stromal cells with myofibroblastic differentiation features are the predominant cell type at the periphery of epithelial tumors. These tumor-activated fibroblasts play a major role in tumor development and spread, affecting the proliferation, differentiation, invasion or regression of cancer cells. This review considers the events inducing the different fibroblastic responses and the role of tumor-activated fibroblasts in both tumor development and anti-cancer treatments.
在许多浸润性癌中可见的显著促纤维增生性或间质反应表明，间质细胞在癌症发病机制中发挥作用。基于细胞分型的研究，使用针对细胞骨架成分的抗体，已揭示大多数肿瘤含有多种类型的成纤维细胞。具有肌成纤维细胞分化特征的间质细胞是上皮性肿瘤周边的主要细胞类型。这些肿瘤激活的成纤维细胞在肿瘤发展和扩散中起主要作用，影响癌细胞的增殖、分化、侵袭或消退。本综述探讨了诱导不同成纤维细胞反应的事件以及肿瘤激活的成纤维细胞在肿瘤发展和抗癌治疗中的作用。
