Mishra Pravin J, Mishra Prasun J, Glod John W, Banerjee Debabrata
Department of Medicine, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 8903, USA.
Cancer Res. 2009 Feb 15;69(4):1255-8. doi: 10.1158/0008-5472.CAN-08-3562. Epub 2009 Feb 10.
Tumor-associated fibroblasts or carcinoma-associated fibroblasts (CAF) play an important role in the growth of epithelial solid tumors. Although the cell type of origin of CAFs has not been conclusively established, it has been shown that they may be bone marrow derived. One side of the mesenchymal stem cell (MSC) coin is the well-accepted therapeutic potential of these cells for regenerative and immunomodulatory purposes. The ominous dark side is revealed by the recent work demonstrating that hMSCs may be a source of CAFs. In this review, we discuss the role of stromal cells in the tumor microenvironment and suggest that by exploring the in vitro/in vivo interplay between different cell types within the tumor milieu, strategies for improved tumor therapy can be developed.
肿瘤相关成纤维细胞或癌相关成纤维细胞（CAF）在上皮性实体瘤的生长中发挥着重要作用。尽管CAF的起源细胞类型尚未最终确定，但已有研究表明它们可能来源于骨髓。间充质干细胞（MSC）的一面是其用于再生和免疫调节目的的公认治疗潜力。而其不祥的阴暗面则通过最近的研究得以揭示，即人骨髓间充质干细胞（hMSC）可能是CAF的一个来源。在这篇综述中，我们讨论了基质细胞在肿瘤微环境中的作用，并提出通过探索肿瘤微环境中不同细胞类型之间的体外/体内相互作用，可以开发出改善肿瘤治疗的策略。
