Hayashi K, Nagamatsu T, Honda S, Suzuki Y
Department of Pharmacology, Meijo University, Nagoya, Japan.
Jpn J Pharmacol. 1996 Jan;70(1):55-64. doi: 10.1254/jjp.70.55.
Effects of butein on crescentic-type anti-glomerular basement membrane (GBM) nephritis in rats were investigated. When rats were treated with butein from 1 day after i.v. injection of anti-GBM serum, it inhibited the elevation of protein excretion into urine. In the butein-treated rats, cholesterol content in plasma was lower than that of the nephritic control rats. Histological observation demonstrated that this agent suppressed the incidence of crescent formation, adhesion of capillary wall to Bowman's capsule and fibrinoid necrosis in the glomeruli. Furthermore, butein suppressed the accumulation of leukocytes, including CD4-positive cells and CD8-positive cells in the glomeruli. However, butein failed to suppress the production of the antibody against rabbit gamma-globulin and the deposition of rat-IgG on the GBM. These results suggest that butein may be a useful medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with diffuse crescents.
研究了白杨素对大鼠新月体型抗肾小球基底膜（GBM）肾炎的影响。在大鼠静脉注射抗GBM血清后第1天用白杨素进行治疗，它抑制了尿蛋白排泄的升高。在白杨素治疗的大鼠中，血浆胆固醇含量低于肾炎对照大鼠。组织学观察表明，该药物抑制了新月体形成的发生率、毛细血管壁与鲍曼囊的粘连以及肾小球中的纤维蛋白样坏死。此外，白杨素抑制了肾小球中白细胞的积聚，包括CD4阳性细胞和CD8阳性细胞。然而，白杨素未能抑制抗兔γ球蛋白抗体的产生以及大鼠IgG在GBM上的沉积。这些结果表明，白杨素可能是一种治疗快速进行性肾小球肾炎的有效药物，这种肾炎的特征是伴有弥漫性新月体的严重肾小球病变。
