Hayashi K, Nagamatsu T, Ito M, Hattori T, Suzuki Y
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Jpn J Pharmacol. 1994 Jun;65(2):143-51. doi: 10.1254/jjp.65.143.
Effects of acetoside (ACT) on crescentic-type anti-GBM nephritis in rats were investigated. When rats were treated with ACT from the 1st day after i.v. injection of anti-GBM serum, ACT inhibited the elevation of protein excretion into urine. In the ACT-treated rats, cholesterol and creatinine contents and antibody production against rabbit gamma-globulin in the plasmas were lower than those of the nephritic control rats. Histological observation demonstrated that this agent suppressed hypercellularity and the incidence of crescent formation, adhesion of capillary wall to Bowman's capsule and fibrinoid necrosis in the glomeruli. Furthermore, rat-IgG and C3 deposits on the GBM were significantly less in the ACT-treated group than in the control nephritic group. When the treatment was started from the 20th day after i.v. injection of anti-GBM serum, by which the disease had been established, ACT resulted in a similar effect on the nephritic rats as stated above. These results suggest that ACT may be a useful medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with diffuse crescents.
研究了紫丁香苷（ACT）对大鼠新月体型抗肾小球基底膜（GBM）肾炎的影响。当大鼠在静脉注射抗GBM血清后第1天开始用ACT治疗时，ACT抑制了尿蛋白排泄的升高。在接受ACT治疗的大鼠中，血浆中的胆固醇和肌酐含量以及针对兔γ球蛋白的抗体产生低于肾炎对照大鼠。组织学观察表明，该药物抑制了细胞增多以及新月体形成的发生率、毛细血管壁与鲍曼囊的粘连和肾小球中的纤维蛋白样坏死。此外，接受ACT治疗的组中GBM上的大鼠IgG和C3沉积物明显少于对照肾炎组。当从静脉注射抗GBM血清后第20天开始治疗时（此时疾病已经确立），ACT对肾炎大鼠产生了与上述相似的效果。这些结果表明，ACT可能是一种治疗快速进行性肾小球肾炎的有用药物，该疾病的特征是具有弥漫性新月体的严重肾小球病变。
