Pirich C, Efthimiou Y, O'Grady J, Zielinski C, Sinzinger H
Wilhelm Auerswald Atherosclerosis Research Group (ASF), Vienna, Austria.
Thromb Res. 1996 Jan 15;81(2):213-18. doi: 10.1016/0049-3848(95)00238-3.
Disturbances in lipid and lipoprotein metabolism being reported for HIV-1 infection are a common sign of severe infections. Apolipoprotein A being the main constituent protein of HDL has been described to function as the prostaglandinI2 (PGI2)-stabilising factor. PGI2 is not only one of the most potent biological antiaggregatory substances but seems to exert cell-protective properties in the central nervous system, too. PGI2 half-life as well as lipid [total-cholesterol (total-c), triglycerides] and (apo)lipoprotein [LDL-c, HDL-c and apolipoprotein (apo) AI] levels were investigated in 14 HIV-1 positive patients (13 males, 1 female, aged from 29 to 57 yrs). Patients exhibited decreased levels of total-c, LDL-c, HDL-c and apo AI, respectively, while elevated triglyceride levels were observed. PGI2 half-life was shortened (median 53, range: 15-161 seconds) in the patients' plasma as compared with normal controls ranging from 9-12 minutes. In patients with neurological manifestation (n = 8) the decrease of PGI2 half-life (median: 34 seconds, range: 15-67 seconds) was significantly more pronounced (p < 0.05) than in patients (n = 6) with the absence of any central nervous manifestation (median: 83.5, range: 29-161 seconds). The dramatic changes in both HDL-c and apolipoprotein AI as seen during HIV-1 infection are likely to impair PGI2-stabilisation thus being associated with the presence of peripheral neuropathy, dementia and haemostatic imbalance.
据报道，HIV-1感染导致的脂质和脂蛋白代谢紊乱是严重感染的常见迹象。载脂蛋白A作为高密度脂蛋白的主要组成蛋白，被描述为前列腺素I2（PGI2）的稳定因子。PGI2不仅是最有效的生物抗聚集物质之一，而且似乎在中枢神经系统中也具有细胞保护特性。对14名HIV-1阳性患者（13名男性，1名女性，年龄在29至57岁之间）的PGI2半衰期以及脂质[总胆固醇（总c）、甘油三酯]和（载）脂蛋白[低密度脂蛋白c、高密度脂蛋白c和载脂蛋白（apo）AI]水平进行了研究。患者的总c、低密度脂蛋白c、高密度脂蛋白c和apo AI水平分别降低，同时观察到甘油三酯水平升高。与正常对照的9至12分钟相比，患者血浆中PGI2半衰期缩短（中位数53秒，范围：15至161秒）。有神经学表现的患者（n = 8）中PGI2半衰期的降低（中位数：34秒，范围：15至67秒）比无任何中枢神经表现的患者（n = 6）（中位数：83.5秒，范围：29至161秒）明显更显著（p < 0.05）。HIV-1感染期间观察到的高密度脂蛋白c和载脂蛋白AI的显著变化可能会损害PGI2的稳定性，从而与周围神经病变、痴呆和止血失衡的存在有关。
