Lesser G J
Section of Hematology/Oncology, Bowman-Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Neurosurg Clin N Am. 1996 Jul;7(3):527-36.
With proper staging, patients with parenchymal brain metastases from solid tumors are usually found to have widespread extracranial disease. Systemic chemotherapy offers the potential advantage of simultaneous therapy of both intracranial and extracranial tumor. Limited data is available on the efficacy of drug therapy alone in this patient population for selected patients with chemosensitive malignancies and brain metastases, systemic chemotherapy administration represents a useful treatment modality when given at presentation or following recurrence after surgery or radiation therapy.
通过适当的分期，实体瘤脑实质转移患者通常被发现存在广泛的颅外疾病。全身化疗具有同时治疗颅内和颅外肿瘤的潜在优势。对于特定的对化疗敏感的恶性肿瘤和脑转移患者群体，关于单纯药物治疗疗效的可用数据有限，当在初次就诊时或手术或放疗后复发时给予全身化疗，它是一种有用的治疗方式。
