上皮细胞极性的产生：蛋白质运输、膜细胞骨架及E-钙黏蛋白介导的细胞黏附的作用 - Suppr

Generation of epithelial cell polarity: roles for protein trafficking, membrane-cytoskeleton, and E-cadherin-mediated cell adhesion.

作者信息

Mays R W, Nelson W J, Marrs J A

机构信息

Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, California 94305-5426, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 1995;60:763-73. doi: 10.1101/sqb.1995.060.01.082.

DOI:10.1101/sqb.1995.060.01.082

PMID:8824451

Abstract

摘要

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Generation of epithelial cell polarity: roles for protein trafficking, membrane-cytoskeleton, and E-cadherin-mediated cell adhesion.上皮细胞极性的产生：蛋白质运输、膜细胞骨架及E-钙黏蛋白介导的细胞黏附的作用

Cold Spring Harb Symp Quant Biol. 1995;60:763-73. doi: 10.1101/sqb.1995.060.01.082.

Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia.区分膜细胞骨架和钙黏蛋白介导的细胞间黏附在极化上皮细胞中产生不同钠钾ATP酶分布方面的作用。

J Cell Biol. 1993 Oct;123(1):149-64. doi: 10.1083/jcb.123.1.149.

Apiconuclear organization of microtubules does not specify protein delivery from the trans-Golgi network to different membrane domains in polarized epithelial cells.微管的顶核组织并未规定从反式高尔基体网络向极化上皮细胞中不同膜结构域的蛋白质运输。

Mol Biol Cell. 1998 Mar;9(3):685-99. doi: 10.1091/mbc.9.3.685.

Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankyrin, and fodrin in Madin-Darby canine kidney epithelial cells.在犬肾上皮细胞中鉴定出一种包含细胞粘附分子桥粒芯糖蛋白（E-钙粘蛋白）、锚蛋白和血影蛋白的膜细胞骨架复合体。

J Cell Biol. 1990 Feb;110(2):349-57. doi: 10.1083/jcb.110.2.349.

Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility.钠钾ATP酶β亚基对于上皮细胞极化、抑制侵袭及细胞运动是必需的。

Mol Biol Cell. 2001 Feb;12(2):279-95. doi: 10.1091/mbc.12.2.279.

Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells.参与在MDCK上皮细胞中产生钠钾ATP酶极性的机制层次结构。

J Cell Biol. 1995 Sep;130(5):1105-15. doi: 10.1083/jcb.130.5.1105.

Biogenesis of polarized epithelial cells during kidney development in situ: roles of E-cadherin-mediated cell-cell adhesion and membrane cytoskeleton organization.原位肾脏发育过程中极化上皮细胞的生物发生：E-钙黏蛋白介导的细胞间黏附及膜细胞骨架组织的作用

Mol Biol Cell. 1998 Nov;9(11):3161-77. doi: 10.1091/mbc.9.11.3161.

The polarity of the retinal pigment epithelium.

Traffic. 2001 Dec;2(12):867-72. doi: 10.1034/j.1600-0854.2001.21202.x.

Biogenesis of epithelial cell surface polarity.

Harvey Lect. 1993;89:125-46.

Regulation of epithelial cell polarity: a view from the cell surface.

Cold Spring Harb Symp Quant Biol. 1992;57:621-30. doi: 10.1101/sqb.1992.057.01.068.

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Btbd7 contributes to reduced E-cadherin expression and predicts poor prognosis in non-small cell lung cancer.Btbd7导致E-钙黏蛋白表达降低，并预示非小细胞肺癌的预后不良。

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cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac.cAMP 信号通过激活 Epac 保护近端肾小管上皮细胞免受顺铂诱导的细胞凋亡。

Br J Pharmacol. 2012 Feb;165(4b):1137-50. doi: 10.1111/j.1476-5381.2011.01594.x.

Overexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancer.DPAGT1的过表达导致口腔癌中E-钙黏蛋白的异常N-糖基化和细胞分离。

Cancer Res. 2009 Jul 15;69(14):5673-80. doi: 10.1158/0008-5472.CAN-08-4512. Epub 2009 Jun 23.

Cell adhesion molecules in chemically-induced renal injury.化学诱导性肾损伤中的细胞黏附分子

Pharmacol Ther. 2007 Apr;114(1):74-93. doi: 10.1016/j.pharmthera.2007.01.001. Epub 2007 Jan 23.

Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron.E-钙黏蛋白、N-钙黏蛋白和β-连环蛋白在大鼠肾单位近端和远端节段中的差异表达

BMC Physiol. 2004 May 17;4:10. doi: 10.1186/1472-6793-4-10.

Basolateral membrane expression of a K+ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain.钾离子通道Kir 2.3在基底外侧膜的表达由一个胞质COOH末端结构域引导。

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10475-80. doi: 10.1073/pnas.181481098. Epub 2001 Aug 14.

Dynamics of glycine receptor insertion in the neuronal plasma membrane.甘氨酸受体插入神经元质膜的动态过程。

J Neurosci. 2001 Jul 15;21(14):5036-44. doi: 10.1523/JNEUROSCI.21-14-05036.2001.

Isolation of Neisseria gonorrhoeae mutants that show enhanced trafficking across polarized T84 epithelial monolayers.淋病奈瑟菌突变体的分离，这些突变体显示出在极化的T84上皮单层细胞间转运增强。

Infect Immun. 2000 Feb;68(2):896-905. doi: 10.1128/IAI.68.2.896-905.2000.

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Generation of epithelial cell polarity: roles for protein trafficking, membrane-cytoskeleton, and E-cadherin-mediated cell adhesion.

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