van Jaarsveld H, Kuyl J M, Schulenburg D H, Wiid N M
Department of Chemical Pathology, University of the Orange Free State, Bloemfontein, Republic of South Africa.
Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):65-75.
There is evidence that flavonoid intake correlates inversely with coronary heart disease risk. Flavonoids are widely distributed in food and drinks and act as antioxidants and iron chelators. The aim of this study was to determine whether pycnogenol (a flavonoid extracted from the bark of Pinus pinaster) and catechin could minimise the myocardial mitochondrial damage due to ischemia/reperfusion. Using the rat heart model of ischemia/reperfusion we found that pycnogenol had no significant effect on the resultant damage, while catechin suppressed the observed elevation of low molecular weight iron during ischemia/reperfusion which might explain the significantly reduced mitochondrial injury when using catechin in the perfusate. Our results suggest that some flavonoids might be effective in minimizing ischaemic/reperfusion injury and would require further detailed investigation.
有证据表明，黄酮类化合物的摄入量与冠心病风险呈负相关。黄酮类化合物广泛分布于食物和饮料中，具有抗氧化剂和铁螯合剂的作用。本研究的目的是确定碧萝芷（一种从海岸松的树皮中提取的黄酮类化合物）和儿茶素是否能将缺血/再灌注引起的心肌线粒体损伤降至最低。使用大鼠缺血/再灌注心脏模型，我们发现碧萝芷对由此产生的损伤没有显著影响，而儿茶素抑制了缺血/再灌注期间观察到的低分子量铁的升高，这可能解释了在灌注液中使用儿茶素时线粒体损伤显著减少的原因。我们的结果表明，一些黄酮类化合物可能有效地将缺血/再灌注损伤降至最低，这需要进一步详细研究。
