红酒多酚化合物对心血管系统的保护作用。
Protective effects of red wine polyphenolic compounds on the cardiovascular system.
作者信息
Zenebe W, Pechánová O, Bernátová I
机构信息
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
出版信息
Exp Clin Cardiol. 2001 Fall;6(3):153-8.
Phenolic phytochemicals are widely distributed in the plant kingdom. In terms of protective effects on organisms, the group of polyphenols is the most important. In various experiments, it has been shown that selected polyphenols, mainly flavonoids, confer protective effects on the cardiovascular system and have anti-cancer, antiviral and antiallergic properties. In coronary artery disease, the protective effects are due mainly to antithrombic, antioxidant, anti-ischemic and vasorelaxant properties of flavonoids. Flavonoids are low molecular weight compounds composed of a three-ring structure with various substitutions, which appear to be responsible for the antioxidant and antiproliferative properties. It has been hypothesized that the low incidence of coronary artery disease in the French population may be partially related to the pharmacological properties of polyphenolic compounds present in red wine. Many epidemiological studies have shown that regular flavonoid intake is associated with reduced risk of cardiovascular diseases.
酚类植物化学物质广泛分布于植物界。就对生物体的保护作用而言，多酚类是最重要的一类。在各种实验中，已表明某些选定的多酚，主要是黄酮类化合物，对心血管系统具有保护作用，并具有抗癌、抗病毒和抗过敏特性。在冠状动脉疾病中，保护作用主要归因于黄酮类化合物的抗血栓形成、抗氧化、抗缺血和血管舒张特性。黄酮类化合物是由具有各种取代基的三环结构组成的低分子量化合物，这些取代基似乎赋予了其抗氧化和抗增殖特性。据推测，法国人群中冠状动脉疾病发病率较低可能部分与红酒中存在的多酚类化合物的药理特性有关。许多流行病学研究表明，经常摄入黄酮类化合物与降低心血管疾病风险有关。
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