ten Kate L P, Verheij J B, Wildhagen M F, Hilderink H B, Kooij L, Verzijl J G, Habbema J D
Department of Human Genetics, Free University, Amsterdam, Netherlands.
Hum Hered. 1996 Jan-Feb;46(1):20-5. doi: 10.1159/000154320.
Both single-entry two-step (SETS) couple screening and double-entry two-step (DETS) couple screening have been recommended as methods to screen for cystic fibrosis gene carriers. In this paper we compare the expected results from both types of screening. In general, DETS results in a higher detection rate of couples in which both partners are carriers, but also in a higher proportion of couples with only one identified carrier who have a significant remaining risk in their offspring.
