Dimethyl formamide (DMFA) and ethylene glycol (EG) are estrogenic in rainbow trout.
作者信息
Ren L, Meldahl A, Lech J J
机构信息
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA.
出版信息
Chem Biol Interact. 1996 Sep 27;102(1):63-7. doi: 10.1016/0009-2797(96)03727-1.
PMID:8827063
Abstract
During our studies on the effects of environmental estrogenic chemicals on vitellogenin gene expression in fish, dimethyl formamide (DMFA) and ethylene glycol (EG) were used as solvents to dissolve and deliver hydrophobic beta-estradiol or nonylphenol. Control groups were injected with water only. It was surprising to find that in certain doses, Vg mRNA from control fish can be induced by DMFA or EG alone. This suggested that DMFA and EG are weak estrogens.
摘要
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