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[在软骨钙质沉着症的破坏性关节病中观察到的晶体的鉴定]

[Identification of the crystals observed in the destructive arthropathies of chondrocalcinosis].

作者信息

Gaucher A, Faure G, Netter P, Pourel J, Duheille J

出版信息

Rev Rhum Mal Osteoartic. 1977 Jun;44(6):407-14.

PMID:882816
Abstract

Study of the synovial membrane and cartilage demonstrating two destructive arthropathies of the knee diagnosed in subjects with articular pseudogout. Scanning electron microscopy reveals the presence of many crystals on the surface of the cartilage and the synovium and in the depth of the cartilage. These can be grouped into two families on the basis of dimensions and morphology. The first consists of those shaped like arrowheads and are large (80-100 microns long.) They were formally identified using Weissenberg's technique; dihydrated calcium hydrogenophosphate (CaHPO4.2H2O) is involved here. In the second family the crystallogenesis is different (prism or lozange-shaped) and the crystals themselves have not been identified with certainty because of their tiny size (20 microns). The hypothesis is proposed that the crystals of dihydrated calcium hydrogenophosphate properly belong to the destructive arthropathies of pseudogout; while not necessarily its cause, they may help explain its development.

摘要

对滑膜和软骨的研究显示,在关节假性痛风患者中诊断出两种膝关节破坏性关节病。扫描电子显微镜显示,在软骨和滑膜表面以及软骨深处存在许多晶体。根据尺寸和形态,这些晶体可分为两类。第一类晶体形状像箭头,较大(长80 - 100微米)。它们通过魏森堡技术被正式鉴定;此处涉及磷酸氢钙二水合物(CaHPO4·2H2O)。在第二类中,晶体形成不同(棱柱形或菱形),并且由于其尺寸微小(20微米),晶体本身尚未被明确鉴定。有人提出假说,磷酸氢钙二水合物晶体恰属于假性痛风的破坏性关节病;它们不一定是其病因,但可能有助于解释其发展过程。

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