Girbés T, Ferreras J M, Iglesias R, Citores L, De Torre C, Carbajales M L, Jiménez P, De Benito F M, Muñoz R
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Valladolid, Spain.
Cell Mol Biol (Noisy-le-grand). 1996 Jun;42(4):461-71.
Plant ribosome-inactivating proteins (RIPs) are inhibitors present in all parts of plants that irreversibly inactivate eukaryotic ribosomes, thus impairing protein synthesis. RIPs are enzymes with N-glycosidase activity on the large rRNA. Their powerful inhibitory activity has been made use of advantageously to construct conjugates with suitable carriers targeted to altered specific cells. RIPs may be used to inhibit replication of both animal and plant viruses. The introduction of genes coding for RIPs into the genome of plants leads to an increase in resistance towards fungal pathogens and viruses. RIPs are important tools for the treatment of cancer and AIDS and for the protection of crop production.
植物核糖体失活蛋白（RIPs）是存在于植物各个部位的抑制剂，可不可逆地使真核核糖体失活，从而损害蛋白质合成。RIPs是对大核糖体RNA具有N-糖苷酶活性的酶。它们强大的抑制活性已被有利地用于构建与靶向特定改变细胞的合适载体的缀合物。RIPs可用于抑制动物和植物病毒的复制。将编码RIPs的基因导入植物基因组可提高对真菌病原体和病毒的抗性。RIPs是治疗癌症和艾滋病以及保护作物生产的重要工具。
