Cromlish J A
Dept of Biochemistry, McGill University, Montreal, Quebec, Canada.
Trends Microbiol. 1996 Jul;4(7):270-4. doi: 10.1016/0966-842x(96)10046-9.
The hepatitis B virus-encoded protein, HBx, may contribute to carcinogenesis by perturbing cell growth and differentiation. There is some evidence indicating that HBx represses the nuclear import of the tumour repressor p53 and p53-dependent trans-activation and that HBx activates members of the basic region-leucine zipper (bZIP) family.
乙型肝炎病毒编码的蛋白HBx可能通过扰乱细胞生长和分化而促进癌变。有一些证据表明，HBx抑制肿瘤抑制因子p53的核输入及p53依赖的反式激活，并且HBx激活碱性区域-亮氨酸拉链（bZIP）家族的成员。
