Department of Computer Science, Jamia Millia Islamia, New Delhi, India.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
PLoS One. 2021 Dec 16;16(12):e0261497. doi: 10.1371/journal.pone.0261497. eCollection 2021.
Since the emergence of yellow fever in the Americas and the devastating 1918 influenza pandemic, biologists and clinicians have been drawn to human infecting viruses to understand their mechanisms of infection better and develop effective therapeutics against them. However, the complex molecular and cellular processes that these viruses use to infect and multiply in human cells have been a source of great concern for the scientific community since the discovery of the first human infecting virus. Viral disease outbreaks, such as the recent COVID-19 pandemic caused by a novel coronavirus, have claimed millions of lives and caused significant economic damage worldwide. In this study, we investigated the mechanisms of host-virus interaction and the molecular machinery involved in the pathogenesis of some common human viruses. We also performed a phylogenetic analysis of viral proteins involved in host-virus interaction to understand the changes in the sequence organization of these proteins during evolution for various strains of viruses to gain insights into the viral origin's evolutionary perspectives.
自美洲出现黄热病和 1918 年毁灭性流感大流行以来，生物学家和临床医生一直致力于研究感染人类的病毒，以更好地了解它们的感染机制，并开发针对这些病毒的有效疗法。然而，自从发现第一种感染人类的病毒以来，这些病毒在人类细胞中感染和繁殖所使用的复杂分子和细胞过程一直是科学界关注的焦点。病毒疾病的爆发，如最近由新型冠状病毒引起的 COVID-19 大流行，已经在全球范围内夺走了数百万人的生命并造成了巨大的经济损失。在这项研究中，我们研究了宿主-病毒相互作用的机制以及参与一些常见人类病毒发病机制的分子机制。我们还对参与宿主-病毒相互作用的病毒蛋白进行了系统发育分析，以了解这些蛋白在进化过程中序列组织的变化，从而深入了解病毒起源的进化视角。
