Functions of ionotropic and metabotropic glutamate receptors in sensory transmission in the mammalian thalamus.

The thalamic relay nuclei play a pivotal role in gating and processing sensory information en route to the cerebral cortex. The major ascending sensory afferents and the descending cortico-fugal afferents to the thalamus almost certainly use the excitatory amino acid L-glutamate as their transmitter. This paper reviews the nature of this transmission in terms of the receptor types which may be used (NMDA, AMPA, kainate and metabotropic glutamate receptors), their electrophysiological and pharmacological properties, and their differential location in the thalamus on neurones, terminals and glial elements. Whilst AMPA receptors, probably of more than one variety, are likely to mediate fast transmission in the thalamus, the contributions of NMDA receptors and metabotropic glutamate receptors to sensory responses under different stimulus conditions may be more varied. This is discussed in the context of the possible functional significance of the interplay of L-glutamate-gated currents with intrinsic membrane currents of thalamic neurones. The interaction of L-glutamate transmission with other modulators (acetylcholine, noradrenaline, serotonin, glycine, D-serine, nitric oxide, arginine, redox agents) is considered.