Bajalica-Lagercrantz S, Tingaard Pedersen N, Sørensen A G, Nordenskjöld M
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Cancer Genet Cytogenet. 1996 Sep;90(2):102-5. doi: 10.1016/s0165-4608(96)00092-1.
We report a case of peripheral T-cell lymphoma that was initially found to have the aberrant karyotype 47,XX,t(2;13)(q22;q22),+19. At relapse 2 years later, a malignant clone with the karyotype 46,XX,der(22)t(2;22)(q31;q13) was identified. This rearrangement leads to a duplication of the distal part of the long arm of chromosome 2. We used chromosome-specific painting libraries and multicolor fluorescence in situ hybridization, as a complement to banding analysis, to resolve the karyotype.
我们报告了一例外周T细胞淋巴瘤病例，该病例最初被发现具有异常核型47,XX,t(2;13)(q22;q22),+19。2年后复发时，鉴定出一个核型为46,XX,der(22)t(2;22)(q31;q13)的恶性克隆。这种重排导致2号染色体长臂远端部分的重复。我们使用染色体特异性涂染文库和多色荧光原位杂交作为带型分析的补充，以解析核型。
