Grammatico P, Lombardo A, Governatori M, Mordenti C, Poscente M, Del Porto G
Experimental Medicine and Pathology Department, University La Sapienza, Rome, Italy.
Cancer Genet Cytogenet. 1996 Sep;90(2):132-4. doi: 10.1016/s0165-4608(96)90071-0.
To contribute to the knowledge on tumorigenesis and the evolution of urothelial carcinoma of the ureter, we analyzed the clinical, histological, and cytogenetic aspects of a case. Primary cell cultures obtained from tumor specimens showed a trisomy of chromosome 20 where the c-src proto-oncogene, already described in literature as having an important role in the etiology and progression of some tumors, is located. In our case trisomy 20 is the only present marker and for this reason we think that it could play a role in the tumorigenesis of the urothelial carcinoma of the ureter.
为了增进对输尿管尿路上皮癌肿瘤发生及演变的认识，我们分析了1例病例的临床、组织学及细胞遗传学特征。从肿瘤标本中获取的原代细胞培养显示20号染色体三体，文献中已描述的在某些肿瘤的病因及进展中起重要作用的c-src原癌基因就位于该染色体上。在我们的病例中，20号染色体三体是唯一存在的标志物，因此我们认为它可能在输尿管尿路上皮癌的肿瘤发生中起作用。
