Sandberg A A, Berger C S, Haddad F S, Kerr D, Hecht F
Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):335-40. doi: 10.1016/0165-4608(86)90063-4.
Primary transitional cell carcinoma of the ureter is a relatively rare cancer. A case of transitional cell carcinoma of the mid-portion of the ureter in an adult male has been studied cytogenetically and has been found to have trisomy of chromosome #7 (+7) as the only karyotypic abnormality. In an earlier instance of transitional cell carcinoma of the ureter, we observed trisomy 7 together with monosomy 9 and an isochromosome for 5p. The relation of this observation to the cytogenetic findings in transitional cell carcinoma of the bladder is discussed and their possible significance evaluated. The rarity of the cytogenetic findings in these tumors is stressed, as is the possible role played by the chromosomal change in this condition, which may possibly involve the c-erb B oncogene.
原发性输尿管移行细胞癌是一种相对罕见的癌症。对一名成年男性输尿管中段移行细胞癌病例进行了细胞遗传学研究，发现其唯一的核型异常是7号染色体三体（+7）。在早期的一例输尿管移行细胞癌中，我们观察到7号染色体三体，同时伴有9号染色体单体和5号染色体短臂等臂染色体。本文讨论了这一观察结果与膀胱移行细胞癌细胞遗传学发现的关系，并评估了它们可能的意义。强调了这些肿瘤细胞遗传学发现的罕见性，以及这种情况下染色体变化可能发挥的作用，这可能涉及c-erb B癌基因。
