Lo C M, Fan S T, Chan J K, Wei W, Lo R J, Lai C L
Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Transplantation. 1996 Sep 15;62(5):696-8. doi: 10.1097/00007890-199609150-00029.
The major limitation of adult-to-adult living donor liver transplantation is the adequacy of the size of the graft that can be safely harvested from the donor. The present report describes a 22-year-old woman with stage 4 hepatic coma due to fulminant hepatic failure who was successfully treated using a small-for-size left lobe graft from her father. The graft weight was 0.6% of the recipient's body weight, or 25% of her ideal liver weight. Avoidance of warm ischemia, short cold ischemic time, and early treatment of rejection are important elements in optimizing small-for-size graft function. Since the left lobe represents 23-36% of the total liver volume of an adult, it is possible, in most cases, to harvest a left lobe graft of adequate size from a donor of similar size as the recipient.
成人对成人活体供肝肝移植的主要限制在于能够安全地从供体获取的移植物大小是否足够。本报告描述了一名因暴发性肝衰竭导致4期肝昏迷的22岁女性，她接受了来自其父亲的小体积左叶移植物，并成功接受治疗。移植物重量为受者体重的0.6%，或其理想肝脏重量的25%。避免热缺血、缩短冷缺血时间以及早期治疗排斥反应是优化小体积移植物功能的重要因素。由于左叶占成体肝脏总体积的23% - 36%，在大多数情况下，有可能从与受者体型相似的供体获取大小足够的左叶移植物。
