Verkes R J, Pijl H, Meinders A E, Van Kempen G M
Department of Psychiatry, University Hospital Leiden, The Netherlands.
Biol Psychiatry. 1996 Aug 1;40(3):173-80. doi: 10.1016/0006-3223(95)00384-3.
This study examined the relationship between borderline and impulsive personality traits on the one hand, and monoamine function on the other in 15 women with bulimia nervosa and 15 women with recurrent suicidal behavior. Platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were used as peripheral measures of monoaminergic function. All suicide attempters were diagnosed as having a borderline personality disorder, whereas this diagnosis was less frequent in bulimics. Bulimics with borderline comorbidity resembled recurrent suicide attempters with borderline personality disorder more closely in both psychological (anger, impulsive behavior) and biochemical characteristics (platelet 5-HT) than bulimics without borderline personality disorder. Platelet 5-HT was higher in patients with borderline personality than in normal female controls and was positively correlated with the disposition to experience anger. Impulsive personality traits were consistently negatively correlated with platelet MAO activity. Our findings support the subdivision of bulimics according to the presence of borderline or "multi-impulsive" personality disorder.
本研究调查了15名神经性贪食症女性和15名复发性自杀行为女性中，一方面边缘型与冲动型人格特质，另一方面单胺功能之间的关系。血小板5-羟色胺（5-HT）和血小板单胺氧化酶（MAO）活性被用作单胺能功能的外周指标。所有自杀未遂者均被诊断为患有边缘型人格障碍，而在神经性贪食症患者中这种诊断则较少见。与无边缘型人格障碍的神经性贪食症患者相比，合并边缘型人格障碍的神经性贪食症患者在心理（愤怒、冲动行为）和生化特征（血小板5-HT）方面更类似于患有边缘型人格障碍的复发性自杀未遂者。边缘型人格障碍患者的血小板5-HT高于正常女性对照组，且与愤怒体验倾向呈正相关。冲动型人格特质始终与血小板MAO活性呈负相关。我们的研究结果支持根据边缘型或“多重冲动型”人格障碍的存在对神经性贪食症患者进行细分。
