Lepage J Y, Malinovsky J M, Malinge M, Lechevalier T, Dupuch C, Cozian A, Pinaud M, Souron R
Department of Anesthesiology, Hôtel-Dieu, Centre Hospitalier et Universitaire de Nantes, France.
Anesth Analg. 1996 Oct;83(4):823-9. doi: 10.1097/00000539-199610000-00030.
After administration of doses ranging from 0.025 to 0.25 mg/kg, the neuromuscular blocking effect of cisatracurium was assessed in 119 adult surgical patients receiving N2O-opioid-midazolam-thiopental anesthesia. The calculated 95% effective dose (ED95) for inhibition of adductor pollicis twitch evoked at 0.1 Hz was 0.053 mg/kg. With 0.10 mg/kg injected over 5-10 and 20-30 s, median onset times (range) were 5.8 (3.0-7.7) and 4.8 (1.2-10.2) min, respectively, and median times to 5% and 95% recovery (range) were 27 (19-46) and 48 (25-68) min, respectively. For doses of 0.10, 0.20, and 0.25 mg/kg, median 5%-95% and 25%-75% recovery indexes ranged from 48 to 90 min and 8 to 9 min, respectively. After administration of neostigmine (0.06 mg/kg) at 10%-15% or 16%-30% recovery, the median times to 95% recovery (range) were 6 (2-22) and 4 (2-5) min, respectively. There were no changes in heart rate, blood pressure, or plasma histamine concentrations during the first 5 min after administration of cisatracurium at doses up to 5 x ED95 injected over 5-10 s. No cutaneous flushing or bronchospasm was noted. In summary, cisatracurium is a potent neuromuscular blocking drug with an intermediate duration of action, characterized by excellent cardiovascular stability, with no apparent histamine release.
在对119例接受氧化亚氮-阿片类药物-咪达唑仑-硫喷妥钠麻醉的成年外科患者给予0.025至0.25mg/kg不等剂量的顺式阿曲库铵后，评估其神经肌肉阻滞作用。抑制拇内收肌在0.1Hz频率下诱发抽搐的计算95%有效剂量（ED95）为0.053mg/kg。分别以0.10mg/kg在5 - 10秒和20 - 30秒内注射，中位起效时间（范围）分别为5.8（3.0 - 7.7）分钟和4.8（1.2 - 10.2）分钟，至5%和95%恢复的中位时间（范围）分别为27（19 - 46）分钟和48（25 - 68）分钟。对于0.10、0.20和0.25mg/kg的剂量，中位5% - 95%和25% - 75%恢复指数分别为48至90分钟和8至9分钟。在恢复至10% - 15%或16% - 30%时给予新斯的明（0.06mg/kg）后，至95%恢复的中位时间（范围）分别为6（2 - 22）分钟和4（2 - 5）分钟。在以高达5倍ED95的剂量经5 - 10秒注射顺式阿曲库铵后的最初5分钟内，心率、血压或血浆组胺浓度无变化。未观察到皮肤潮红或支气管痉挛。总之，顺式阿曲库铵是一种强效神经肌肉阻滞药物，作用持续时间中等，具有出色的心血管稳定性，且无明显组胺释放。
