Proshina L Ia
Vopr Med Khim. 1977 Mar-Apr;23(2):155-9.
Effect of hydrocortisone on content of serotonin was studied in eye vascular tract or blood and the monoamine oxidase (MAO) activity was estimated in eye vascular tract of young and adult rabbits at various periods after administration of hydrocortisone under conjunctiva. After administration of hydrocortisone content of serotonin was increased in eye vascular tract and decreased in blood. Maximal serotonin reaction was observed in vascular tract of adult rabbits within 24 hrs after the hydrocortisone treatment and in one-month-old rabbits--within 4-6 hrs. In blood of adult animals the most distinct decrease in serotonin content was found within 4-6 hrs after the single administration of the preparation; in one-month-old rabbits the effect was observed after the repeated treatment within 7 days. Effect of hydrocortisone on the MAO activity in eye vascular tract varied depending on the age. In one-month-old rabbits the MAO activity was increased distinctly within 24 hrs after single administration of the preparation and in adult animals the enzyme activity was decreased within 4-6 hrs and did not alter at the other periods after the hydrocortisone administration.
研究了氢化可的松对兔眼血管组织及血液中血清素含量的影响，并评估了成年兔和幼兔在结膜下给予氢化可的松后不同时间段眼血管组织中的单胺氧化酶（MAO）活性。给予氢化可的松后，兔眼血管组织中血清素含量升高，血液中血清素含量降低。氢化可的松处理后24小时内，成年兔血管组织中观察到最大血清素反应，1月龄兔在4 - 6小时内观察到最大反应。成年动物单次给药后4 - 6小时内，血液中血清素含量下降最为明显；1月龄兔在7天内重复给药后观察到该效应。氢化可的松对眼血管组织中MAO活性的影响因年龄而异。1月龄兔单次给药后24小时内MAO活性明显升高，成年动物给药后4 - 6小时酶活性降低，给药后其他时间段酶活性未改变。
