Schaap N, Raymakers R, Schattenberg A, Ottevanger J P, de Witte T
Division of Hematology, University Hospital Nijmegen, The Netherlands.
Bone Marrow Transplant. 1996 Jul;18(1):247-8.
A 37-year-old male developed massive pleural effusion leading to respiratory failure and electromechanical dissociation within 24 h after the second dose of 4200 mg cyclophosphamide (CY) during conditioning for allogeneic bone marrow transplantation for chronic myelogenous leukemia. After resuscitation and bilateral pleural drainage he recovered within 1 day. Subsequently, total body irradiation was given and with a delay of 1 day the transplantation procedure was continued without major complications. No explanation for this idiosyncratic reaction other than the administration of high dose CY in combination with mesna rescue was found. This reaction has not been reported before in the literature.
一名37岁男性在接受慢性粒细胞白血病异基因骨髓移植预处理过程中，第二次输注4200mg环磷酰胺（CY）后24小时内出现大量胸腔积液，导致呼吸衰竭和电机械分离。经过复苏和双侧胸腔引流，他在1天内康复。随后进行了全身照射，并在推迟1天后继续进行移植手术，未出现重大并发症。除了高剂量CY联合美司钠解救治疗外，未发现对此特异反应的其他解释。此前文献中未报道过这种反应。
