Sasaki H, Takeda N, Kawamura I, Nishida Y, Kikuchi K, Tanaka M
Department of Pediatrics, Kurashiki Central Hospital, Japan.
Clin Nephrol. 1996 Jul;46(1):6-9.
The urinary levels of albumin, beta 2-microglobulin (BMG) and beta-D-N-acetyl glucosaminidase (NAG) were studied in 30 children with short stature due to partial or complete growth hormone (GH) deficiency under treatment. All 30 children had a normal urinalysis and no clinical evidence of renal disease. They were treated with recombinant GH in a dose of 0.5 IU/kg/week given subcutaneously. The mean albumin excretion rate (9.13 +/- 8.33 micrograms/min/1.73 m2) of these children was significantly higher than that (4.2 +/- 2.27 micrograms/min/1.73 m2) of 30 age-, sex- and pubertal status-matched normal children (p < 0.01). BMG and NAG excretion was normal in both groups. There was no correlation between the urinary albumin excretion rate and the duration of GH treatment. Among the GH-treated children, the urinary albumin excretion rate was correlated significantly with circulatory insulin-like growth factor I (IGF-I) (r = 0.65, p < 0.01). In 7 other children analyzed before and three months after start of GH treatment, the mean urinary albumin excretion rate increased significantly from 4.71 +/- 3.95 micrograms/min/1.73 m2 to 8.29 +/- 2.70 micrograms/min/1.73 m2 (p < 0.03). These results suggest the possibility of functional glomerular alterations during GH therapy.
对30名因部分或完全生长激素（GH）缺乏而身材矮小且正在接受治疗的儿童的尿白蛋白、β2-微球蛋白（BMG）和β-D-N-乙酰氨基葡萄糖苷酶（NAG）水平进行了研究。所有30名儿童尿常规均正常，无肾脏疾病的临床证据。他们接受皮下注射重组GH治疗，剂量为0.5 IU/kg/周。这些儿童的平均白蛋白排泄率（9.13±8.33微克/分钟/1.73平方米）显著高于30名年龄、性别和青春期状态匹配的正常儿童（4.2±2.27微克/分钟/1.73平方米）（p<0.01）。两组的BMG和NAG排泄均正常。尿白蛋白排泄率与GH治疗持续时间之间无相关性。在接受GH治疗的儿童中，尿白蛋白排泄率与循环胰岛素样生长因子I（IGF-I）显著相关（r = 0.65，p<0.01）。在开始GH治疗前及治疗三个月后分析的另外7名儿童中，尿白蛋白平均排泄率从4.71±3.95微克/分钟/1.73平方米显著增加至8.29±2.70微克/分钟/1.73平方米（p<0.03）。这些结果提示在GH治疗期间可能存在功能性肾小球改变。
