Pan F P, Stevenson J L, Donaldson D L, Levy J, Wiegmann T, Moore W V
University of Kansas Medical Center, Kansas City 66103.
J Clin Endocrinol Metab. 1990 Sep;71(3):611-7. doi: 10.1210/jcem-71-3-611.
We examined the correlation between urinary GH, urinary albumin, and beta-2-microglobulin excretion to determine how the excretion of GH relates to markers of renal glomerular and tubular function. Urinary albumin and GH excretion was determined in timed daytime and nighttime urine collections obtained from both subjects with diabetes mellitus and subjects with short stature. For subjects with diabetes, urinary GH excretion rate correlated highly with urinary albumin concentration and excretion rate in both the range of 0 to 1.6 g/L (r = 0.75), P less than 0.001) and in the microalbuminuria range, 0 to 0.4 g/L (r = 0.53, P less than 0.001). Changes in GH and albumin excretion occurred in parallel in 71% of the subjects with diabetes and elevated albumin excretion. The mean GH excretion rate was higher in the group with elevated albumin excretion rate (AER) during both day and night compared to the group with microalbuminuria during the day and normal AER at night. For subjects with short stature, the mean albumin excretion rate was 0.7 +/- 1.3 micrograms/min (range 0.05-8.3 micrograms/min) using a sensitive enzyme-linked immunosorbent assay to measure albumin concentration. The correlation of GH and albumin excretion rates for the subjects with short stature was not statistically significant (r = 0.14, P less than 0.5). About half of the subjects with diabetes and elevated AER (greater than 10 micrograms/min) had a GH excretion rate within the range observed in subjects with short stature. The GH and albumin excretion rate were not correlated in this group. There was a positive correlation of both albumin and GH excretion rate with age in the subjects with diabetes. Urinary GH and beta-2-microglobulin excretion rates were determined in a larger group of subjects with diabetes and a separate group with short stature. Urinary GH and beta-2-microglobulin excretion were correlated both in subjects with diabetes (r = 0.46, P less than 0.001) and with short stature (r = 0.64, P less than 0.001). The association was present in urine collected either during the day or night. The mean GH excretion rate of the group with diabetes was greater than the group with short stature. In conclusion, there was an association of urinary GH and albumin excretion rate in subjects with abnormal glomerular function as indicated by elevated albumin excretion rate. An association of urinary GH and beta-2-microglobulin excretion was observed in subjects with normal tubular function.(ABSTRACT TRUNCATED AT 400 WORDS)
我们检测了尿生长激素（GH）、尿白蛋白和β2-微球蛋白排泄之间的相关性，以确定GH排泄与肾小球和肾小管功能标志物之间的关系。在从糖尿病患者和身材矮小患者收集的日间和夜间定时尿液样本中，测定尿白蛋白和GH排泄情况。对于糖尿病患者，在尿白蛋白浓度和排泄率范围为0至1.6 g/L（r = 0.75，P < 0.001）以及微量白蛋白尿范围0至0.4 g/L（r = 0.53，P < 0.001）时，尿GH排泄率与尿白蛋白浓度和排泄率均高度相关。在71%的糖尿病且白蛋白排泄增加的患者中，GH和白蛋白排泄变化呈平行关系。与日间微量白蛋白尿且夜间白蛋白排泄率正常的组相比，白蛋白排泄率升高（AER）组在白天和夜间的平均GH排泄率均更高。对于身材矮小患者，使用灵敏的酶联免疫吸附测定法测量白蛋白浓度，其平均白蛋白排泄率为0.7±1.3微克/分钟（范围为0.05 - 8.3微克/分钟）。身材矮小患者的GH和白蛋白排泄率之间的相关性无统计学意义（r = 0.14，P < 0.5）。约一半糖尿病且AER升高（大于10微克/分钟）的患者，其GH排泄率处于身材矮小患者观察到的范围内。该组中GH和白蛋白排泄率不相关。糖尿病患者中白蛋白和GH排泄率均与年龄呈正相关。在一大组糖尿病患者和另一组身材矮小患者中，测定了尿GH和β2-微球蛋白排泄率。糖尿病患者（r = 0.46，P < 0.001）和身材矮小患者（r = 0.64，P < 0.001）的尿GH和β2-微球蛋白排泄均相关。该关联在白天或夜间收集的尿液中均存在。糖尿病组的平均GH排泄率高于身材矮小组。总之，如白蛋白排泄率升高所示，在肾小球功能异常的患者中，尿GH与白蛋白排泄率存在关联。在肾小管功能正常的患者中，观察到尿GH与β2-微球蛋白排泄存在关联。（摘要截短至400字）
