Bishop A, Satyamurthy N, Bida G, Phelps M, Barrio J R
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, USA.
Nucl Med Biol. 1996 May;23(4):385-9. doi: 10.1016/0969-8051(95)02009-8.
For the first time, the 16O(3He,p)18F reaction has been used for the production of 18F electrophilic reagents. The predominant reactive chemical specie recovered in the single-step postirradiation gases was [18F]F2. Decay curve and Ge(Li) analyses established the main radionuclidic impurities in this nuclear reaction as 11C and 15O. Recovery of the 18F activity was exceptionally high, approaching 90% using an electroformed nickel target body. Consistent 18F recoveries for this nuclear reaction (approximately 70%) were realized with a novel aluminum target body. The utility of the [18F]F2 recovered from this oxygen gas target system in radiopharmaceutical preparations is demonstrated by the successful synthesis of 6-[18F]fluoro-L-dopa (11.0 mCi at EOB) via a fluorodemercuration method.
首次将16O(3He,p)18F反应用于18F亲电试剂的制备。在辐照后单步气体中回收的主要活性化学物质是[18F]F2。衰变曲线和锗（锂）分析确定该核反应中的主要放射性核素杂质为11C和15O。18F活度的回收率异常高，使用电铸镍靶体时接近90%。使用新型铝靶体实现了该核反应一致的18F回收率（约70%）。通过氟脱汞法成功合成6-[18F]氟-L-多巴（EOB时为11.0 mCi），证明了从该氧气靶系统回收的[18F]F2在放射性药物制剂中的实用性。
