Keogan M T, Spritzer C E, Paulson E K, Paine S S, Harris L, Dahlke J L, MacFall J R
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Abdom Imaging. 1996 Sep-Oct;21(5):433-9. doi: 10.1007/s002619900098.
The purpose of this study was to compare a fast spin-echo sequence combined with a respiratory triggering device (R. trig. FSE) with conventional T2-weighted spin-echo (CSE) and inversion recovery (STIR) sequences for the detection of focal hepatic lesions.
We performed a prospective study of 33 consecutive patients with known or suspected hepatic tumors. All patients underwent R. trig. FSE, CSE, and STIR imaging at 1.5 T. Acquisition times were 10.7 min for the CSE sequence and ranged from 12 to 15 min for STIR and from 5 to 7 min for R. trig FSE. For each sequence, liver-spleen contrast-to-noise ratio (CNR) and liver-lesion CNR were determined quantitatively. Image artifact and sharpness were graded by using a four-point scale on each sequence by two independent readers. Both readers also independently identified hepatic lesions (up to a maximum of eight per patient). For patients with focal lesions, the total number of lesions detected (on each sequence) and the minimum size of detected lesions were also determined by each reader.
No significant difference was detected between R. trig. FSE and CSE or STIR in either liver-spleen CNR or liver-lesion CNR. R. trig. FSE images were equivalent to CSE and superior to STIR in sharpness (p < 0.01) and presence of artifact (p < 0.01). R. trig. FSE detected a higher number of lesions (reader 1: n = 92, reader 2: n = 86) than CSE (reader 1: n = 70, reader 2: n = 69) and a significantly higher number than STIR (reader 1: n = 71, reader 2: n = 76). Lesion structure was significantly better defined with R. trig. FSE than with STIR (p < 0.01) and CSE (p < 0.05).
Compared with CSE and STIR, R. trig. FSE produces hepatic images of comparable resolution and detects an increased number of focal hepatic lesions in a shorter period of time.
本研究旨在比较快速自旋回波序列结合呼吸触发装置（R.trig.FSE）与传统T2加权自旋回波（CSE）及反转恢复（STIR）序列在检测肝脏局灶性病变方面的效果。
我们对33例已知或疑似肝脏肿瘤的连续患者进行了一项前瞻性研究。所有患者均在1.5T条件下接受R.trig.FSE、CSE和STIR成像。CSE序列采集时间为10.7分钟，STIR序列采集时间为12至15分钟，R.trig.FSE序列采集时间为5至7分钟。对于每个序列，定量测定肝脏-脾脏对比噪声比（CNR）和肝脏-病变CNR。由两名独立阅片者使用四点量表对每个序列的图像伪影和清晰度进行分级。两名阅片者还独立识别肝脏病变（每位患者最多8个）。对于有局灶性病变的患者，每位阅片者还确定检测到的病变总数（每个序列）以及检测到的病变最小尺寸。
在肝脏-脾脏CNR或肝脏-病变CNR方面，R.trig.FSE与CSE或STIR之间未检测到显著差异。R.trig.FSE图像在清晰度（p<0.01）和伪影存在情况（p<0.01）方面与CSE相当且优于STIR。R.trig.FSE检测到的病变数量（阅片者1：n = 92，阅片者2：n = 86）多于CSE（阅片者1：n = 70，阅片者2：n = 69），且显著多于STIR（阅片者1：n = 71，阅片者2：n = 76）。与STIR（p<0.01）和CSE（p<0.05）相比，R.trig.FSE对病变结构的显示明显更好。
与CSE和STIR相比，R.trig.FSE能产生分辨率相当的肝脏图像，并在更短时间内检测到更多的肝脏局灶性病变。
