Appelman Y E, Piek J J, Verhoofstad G G, Gijsbers G H, Van Gemert M J
Department of Cardiology, Academic Medical Center, The Netherlands.
Lasers Surg Med. 1996;18(2):197-205. doi: 10.1002/(SICI)1096-9101(1996)18:2<197::AID-LSM11>3.0.CO;2-5.
The relationship between tissue ablation volume and the formation of insoluble gas of the currently available excimer laser systems is unknown. This aspect was evaluated in two excimer laser systems.
STUDY DESIGN/MATERIALS AND METHODS: We measured tissue ablation volume and gas production of two excimer laser systems (308 nm) on porcine aortic tissue immersed in saline (the CVX-300 using 1.4 and 1.7 mm laser catheters and the Dymer 200 + using 1.3, 1.3z and 1.6 mm laser catheters).
Tissue ablation volume and gas production increased proportionally with the applied energy fluence, ranging from 30-60 mJ/mm2. The gas production per unit of ablated tissue volume of the 1.4 mm laser catheter was significantly higher than the 1.3 mm laser catheter (mean difference +117%, 95% CI from +64% till +188%, P<0.001). The gas production of the 1.7 mm laser catheter was higher than the 1.6 mm laser catheter (mean difference +70%, 95% CI from +28% till +126%, P<0.001). The 1.3z mm laser catheter demonstrated more gas production than the 1.3 mm laser catheter (mean difference +123%, 95% CI from +68% till +196%, P<0.001).
The results of our study indicate that excimer laser with the use of the CVX-300 laser system results in significantly higher gas production than the Dymer 200+ laser system, which can be markedly reduced by lowering the applied energy fluence. The 1.3z laser catheter constitutes an exception, showing similar characteristics as the CVX-300 laser catheters.
目前可用的准分子激光系统中，组织消融体积与不溶性气体形成之间的关系尚不清楚。在两种准分子激光系统中对这一方面进行了评估。
研究设计/材料与方法：我们在浸泡于盐水中的猪主动脉组织上，测量了两种准分子激光系统（308纳米）的组织消融体积和气体产生情况（CVX - 300使用1.4毫米和1.7毫米激光导管，Dymer 200 +使用1.3毫米、1.3z毫米和1.6毫米激光导管）。
组织消融体积和气体产生与所施加的能量密度成比例增加，范围为30 - 60毫焦/平方毫米。1.4毫米激光导管每单位消融组织体积的气体产生量显著高于1.3毫米激光导管（平均差异 +117%，95%置信区间从 +64%至 +188%，P<0.001）。1.7毫米激光导管的气体产生量高于1.6毫米激光导管（平均差异 +70%，95%置信区间从 +28%至 +126%，P<0.001）。1.3z毫米激光导管的气体产生量比1.3毫米激光导管更多（平均差异 +1百分之二十三%，95%置信区间从 +68%至 +196%，P<0.001）。
我们的研究结果表明，使用CVX - 300激光系统的准分子激光产生的气体量显著高于Dymer 200 +激光系统，通过降低所施加的能量密度可显著减少气体产生量。1.3z激光导管是个例外，显示出与CVX - 300激光导管相似的特性。
